An integration-free iPSC line ZZUNEUi008-A derived from dermal fibroblasts of a child with cardiac valvular dysplasia carrying a mutation in FLNA gene
Summary
FLNA gene encodes an actin-binding protein filamin A and mutations in FLNA can causes X-Linked cardiac valvular dysplasia. In this study, we report the generation of ZZUNEUi008-A, a human induced pluripotent stem cell line from a 10-year-old male patient with c. 84G → A in FLNA gene using non-integrative Sendai viral reprogramming technology. The ZZUNEUi008-A iPSC line expresses pluripotency markers, exhibits a normal male karyotype (46, XY) and can differentiate into three germ layers in vivo. Copyright © 2020. Published by Elsevier B.V.
| Authors | Li X, Lu Y, Wang J, Liu M, Wang M, Hu L, Du W, Wang L, Jiang Z, Gu X, Ding Z, Feng D, Li L, Dong J, Zhao X |
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| Journal | Stem cell research |
| Publication Date | 2020 Jun 22;47:101882 |
| PubMed | 32592953 |
| DOI | 10.1016/j.scr.2020.101882 |