An integration-free iPSC line ZZUNEUi008-A derived from dermal fibroblasts of a child with cardiac valvular dysplasia carrying a mutation in FLNA gene


FLNA gene encodes an actin-binding protein filamin A and mutations in FLNA can causes X-Linked cardiac valvular dysplasia. In this study, we report the generation of ZZUNEUi008-A, a human induced pluripotent stem cell line from a 10-year-old male patient with c. 84G → A in FLNA gene using non-integrative Sendai viral reprogramming technology. The ZZUNEUi008-A iPSC line expresses pluripotency markers, exhibits a normal male karyotype (46, XY) and can differentiate into three germ layers in vivo. Copyright © 2020. Published by Elsevier B.V.

Authors Li X, Lu Y, Wang J, Liu M, Wang M, Hu L, Du W, Wang L, Jiang Z, Gu X, Ding Z, Feng D, Li L, Dong J, Zhao X
Journal Stem cell research
Publication Date 2020 Jun 22;47:101882
PubMed 32592953
DOI 10.1016/j.scr.2020.101882

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