Adipocyte-Mediated Electrophysiological Remodeling of PKP-2 Mutant Human Pluripotent Stem Cell-Derived Cardiomyocytes
Summary
Our study shows that hiPSC-CMs from normal and mPKP2 ACM lines exhibit distinct molecular and functional responses to paracrine factors, with differences in RNA expression and electrophysiology. These different responses to paracrine factors may contribute to arrhythmogenic propensity.
| Authors | Morrissette-McAlmon J, Chua CJ, Arking A, Wu SCM, Teuben R, Chen EZ, Tung L, Boheler KR |
|---|---|
| Journal | Biomedicines |
| Publication Date | 2024 Nov 14;12(11) |
| PubMed | 39595168 |
| PubMed Central | PMC11592320 |
| DOI | 10.3390/biomedicines12112601 |