Establishment of non-integrate induced pluripotent stem cell line CSUASOi006-A, from urine-derived cells of a PRPF8-related dominant retinitis pigmentosa patient
Summary
Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by the progressive photoreceptors and pigment epithelial cells dysfunction. Here, we report the human induced pluripotent stem cell line (iPSC) CSUASOi006-A, generated from urine-derived cells (UCs) of a 17-year-old male patient with clinically diagnosed RP carrying point mutation (c.C5792T) in the pre-mRNA processing factor 8 gene (PRPF8). The newly derived CSUASOi006-A cell line has the patient's same mutation (c.C5792T) and could provide useful resources for studying the pathogenic mechanism of PRPF8-related RP. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Zhou Y, Cui Z, Jing Y, Mao S, Chen D, Ding C, Gu J, Chan HF, Tang S, Chen J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Dec;49:102041 |
| PubMed | 33157387 |
| DOI | 10.1016/j.scr.2020.102041 |