Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi002-A) from a patient with spinocerebellar ataxia type 3
Summary
Using a non-integrative reprogramming method, a human iPSC Line, ZZUNEUi002-A, was generated from a 22-year-old male patient with spinocerebellar ataxia type 3 /Machado-Joseph disease (SCA3/MJD). This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype. The iPSC line could be used as a tool for mechanism researching and drug screening. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Wei L, Zhang J, Chen D, Feng L, Wu C, Wang R, Li X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Jun 29;47:101898 |
| PubMed | 32650241 |
| DOI | 10.1016/j.scr.2020.101898 |