Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi002-A) from a patient with spinocerebellar ataxia type 3


Using a non-integrative reprogramming method, a human iPSC Line, ZZUNEUi002-A, was generated from a 22-year-old male patient with spinocerebellar ataxia type 3 /Machado-Joseph disease (SCA3/MJD). This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype. The iPSC line could be used as a tool for mechanism researching and drug screening. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wei L, Zhang J, Chen D, Feng L, Wu C, Wang R, Li X
Journal Stem cell research
Publication Date 2020 Jun 29;47:101898
PubMed 32650241
DOI 10.1016/j.scr.2020.101898

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