Generation of an induced pluripotent stem cell line from an unaffected female whose two sisters suffered spontaneous coronary artery dissections (SCAD) (VCCRIi024-A)
Summary
Spontaneous Coronary Artery Dissection (SCAD) is a poorly understood predominantly female condition that can cause myocardial infarction, often affecting otherwise healthy women. Here, we generated an induced pluripotent stem cell line from a female with two SCAD-affected sisters. This individual has not had a SCAD to date; she is currently 12 years older than when SCAD first manifested in her sisters. This resource provides a valuable control for investigating mechanisms underlying SCAD susceptibility. Copyright © 2025. Published by Elsevier B.V.
| Authors | Bax M, Junday K, Hurley E, Hesselson S, McGrath-Cadell L, Kaidonis X, Tarr I, Giannoulatou E, Iismaa SE, Graham RM |
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| Journal | Stem cell research |
| Publication Date | 2025 Jul 5;87:103770 |
| PubMed | 40627959 |
| DOI | 10.1016/j.scr.2025.103770 |