Generation of iPSC-lines from two independent Takotsubo syndrome patients with recurrent Takotsubo events


The Takotsubo syndrome (TTS) is characterized by acute transient left ventricular dysfunction in the absence of obstructive coronary lesions. An enhanced β-adrenergic signaling and higher sensitivity to catecholamine-induced-toxicity were identified as mechanisms associated with TTS. It is still elusive, whether TTS patients with recurrent events show similar underlying signaling pathomechanism. Induced pluripotent stem cell (iPSC)-lines were generated from skin fibroblasts of two independent female Takotsubo syndrome patients with a severe phenotype characterized by recurrent TTS events. For reprogramming, a non-integrative plasmid technique was used. All generated iPSCs maintained full pluripotency, genomic integrity, and spontaneous in vitro and in vivo differentiation capacity. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Hübscher D, Rebs S, Maurer W, Ghadri JR, Dressel R, Templin C, Streckfuss-Bömeke K
Journal Stem cell research
Publication Date 2020 Apr;44:101746
PubMed 32302918
DOI 10.1016/j.scr.2020.101746

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