Generation of induced pluripotent stem cell lines from a sister pair who suffered post-partum or recurrent Spontaneous Coronary Artery Dissections
Summary
Spontaneous Coronary Artery Dissection (SCAD) results from a bleed within a coronary artery wall that impairs blood flow as it expands. It is the most common cause of myocardial infarction in pregnant women. Here, peripheral blood mononuclear cells from two sisters who had suffered SCADs were reprogrammed using Sendai Virus. Expression of pluripotency markers, capability to differentiate to the three germ layers, and cellular integrity were confirmed. This is the first report of a SCAD family induced pluripotent stem cell (iPSC) cohort, including a sister who suffered post-partum SCAD, and one who suffered from multiple recurrences. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Bax M, Junday K, Iismaa SE, Kaidonis X, Muller D, Hesselson S, Graham RM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Dec;73:103238 |
| PubMed | 37939621 |
| DOI | 10.1016/j.scr.2023.103238 |