Generation of iPSC line (FAMRCi009-A) from patient with familial progressive cardiac conduction disorder carrying genetic variant FLNC p.Val2264Met

Summary

Human iPSC cell line FAMRCi009-A was generated from a patient with restrictive cardiomyopathy and congenital myopathy carrying FLNC p.Val2264Met genetic variant. Patient-specific peripheral blood mononuclear cells were reprogrammed using non-integrative Sendai viruses. Generated iPSC lines showed normal karyotype, expressed pluripotency markers and exhibited trilineage differentiation potential in vitro. The reported iPSC lines could be used for a deeper study of filaminopathies. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Rodina N, Khudiakov A, Perepelina K, Muravyev A, Boytsov A, Zlotina A, Sokolnikova P, Kostareva A
Journal Stem cell research
Publication Date 2021 Dec 27;59:102640
PubMed 34971933
DOI 10.1016/j.scr.2021.102640

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