Generation of iPSC line (FAMRCi009-A) from patient with familial progressive cardiac conduction disorder carrying genetic variant FLNC p.Val2264Met
Summary
Human iPSC cell line FAMRCi009-A was generated from a patient with restrictive cardiomyopathy and congenital myopathy carrying FLNC p.Val2264Met genetic variant. Patient-specific peripheral blood mononuclear cells were reprogrammed using non-integrative Sendai viruses. Generated iPSC lines showed normal karyotype, expressed pluripotency markers and exhibited trilineage differentiation potential in vitro. The reported iPSC lines could be used for a deeper study of filaminopathies. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Rodina N, Khudiakov A, Perepelina K, Muravyev A, Boytsov A, Zlotina A, Sokolnikova P, Kostareva A |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Mar;59:102640 |
| PubMed | 34971933 |
| DOI | 10.1016/j.scr.2021.102640 |