Retinoic acid delays initial photoreceptor differentiation and results in a highly structured mature retinal organoid


This study proves the importance of supplemented media for culturing retinal organoids. More importantly, we demonstrate for the first time that the role of retinoic acid goes beyond inducing a rod cell fate to enhancing the organisation of the photoreceptor layer of the mature organoid. © 2022. The Author(s).

Authors Sanjurjo-Soriano C, Erkilic N, Damodar K, Boukhaddaoui H, Diakatou M, Garita-Hernandez M, Mamaeva D, Dubois G, Jazouli Z, Jimenez-Medina C, Goureau O, Meunier I, Kalatzis V
Journal Stem cell research & therapy
Publication Date 2022 Sep 16;13(1):478
PubMed 36114559
PubMed Central PMC9482314
DOI 10.1186/s13287-022-03146-x

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