Generation of a human induced pluripotent stem cell line (LZUSHi002-A) from a MADD patient with ETFDH mutation
Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is an inborn metabolic disorder that affects fatty acid oxidation and the catabolism of branched-chain amino acids, vitamins B and energy metabolism. In this study, the induced pluripotent stem cell (iPSC) line LZUSHi002-A from PBMCs of a 10-year-old male patient with ETFDH mutations using the episomal plasmids was established, which is an ideal in vitro model to understand the exact pathogenesis of MADD. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
|Authors||Li Y, Li Y, Liu H, Cheng L, Ma H, Xu X, Zhang N|
|Journal||Stem cell research|
|Publication Date||2022 Sep 14;64:102914|