Generation of induced pluripotent stem cell line, ICGi034-A, by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease associated with GBA mutation
Summary
Mutation in the glucocerebrosidase encoding gene (GBA) is one of the most frequent genetic cause of Parkinson's disease. ICGi034-A induced pluripotent stem cell (iPSC) line obtained by reprogramming peripheral blood mononuclear cells (PBMCs) of a patient with heterozygous c.1226A > G (p.N370S) mutation in the GBA gene can be used for studying the fundamental mechanisms of the pathogenesis of GBA-associated Parkinson's disease, and for potential drug screening. The iPSCs express pluripotency markers (NANOG, SSEA4, TRA-1-60, OCT4, SOX2), have a normal karyotype, and are capable of producing derivatives of three germ layers. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Grigor'eva EV, Drozdova ES, Sorogina DA, Malakhova AA, Pavlova SV, Vyatkin YV, Khabarova EA, Rzaev JA, Medvedev SP, Zakian SM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Mar;59:102651 |
| PubMed | 35007918 |
| DOI | 10.1016/j.scr.2021.102651 |