Generation of the induced pluripotent stem cell line (NCKDi002-A) from a 22-year-old patient with Focal Segmental Glomerular Sclerosis carrying a heterozygous mutation in WT1 gene
Summary
Focal Segmental Glomerular Sclerosis (FSGS) is a glomerular disease which can be classified into primary, secondary, genetic, and unknown forms. WT1 mutation has been shown to be associated with this disorder. Recently, we identified a mutation in the Zinc finger C2H2 domain of WT1 gene in a patient with FSGS who also carried a family history of end-stage renal disease (ESRD). The Peripheral Blood Mononuclear Cells (PBMCs) of the patient were obtained and a line of induced pluripotent stem cells (iPSCs) was successfully generated. The iPSC line will be useful for further study of the pathogenesis and drug screening for FSGS. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Wu H, Wang G, Gao E, Zhao J, Zhang L, Chen L, Zhu Y, Zhang J, Liu Z |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 May;53:102293 |
| PubMed | 33780729 |
| DOI | 10.1016/j.scr.2021.102293 |