Establishment of an induced pluripotent stem cell line (SHFDi001-A) from a patient with ankylosing spondylitis


Ankylosing spondylitis (AS) is a highly heritable, inflammatory rheumatic disease, characterized by inflammation of the spine and the sacroiliac joints. Although some genes are reportedly associated with this disease, the pathogenesis of AS remains largely unknown. In this study, the peripheral blood mononuclear cells of a patient with AS were reprogrammed to induced pluripotent stem cells (iPSCs) using transgene-free, episomal plasmid vectors. The established iPSC line was validated by multiple methods and demonstrated typical characteristics of embryonic stem cells. This cell line (SHFDi001-A) may be beneficial in disease modeling and related research. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Hu J, Lu C, Zhu W, Jiang Q, Du W, Wu N
Journal Stem cell research
Publication Date 2020 Jul;46:101879
PubMed 32570173
DOI 10.1016/j.scr.2020.101879

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