Generation of four induced pluripotent stem cells lines from PBMC of the DFNA58 family members: Two hearing-impaired duplication carriers (USPi006-A e USPi007-A) and two normal-hearing noncarriers (USPi004-A and USPi005-A)


The DFNA58 locus contains a genomic duplication involving three protein-coding genes (CNRIP1, PLEK, and PPP3R1's exon 1) and other uncharacterized lncRNA genes (LOC101927723, LOC107985892 and LOC102724389). To clarify the role of these genes in hearing and precisely determine their role in hearing loss, four iPSC lines were generated from two carriers and two noncarriers of the duplication. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Kobayashi GS, Vieira-Silva GA, Varella-Branco E, Moreira DP, Kitajima JPFW, Hemza CRML, Mingroni-Netto RC, Lojudice FH, Oiticica J, Bento RF, Batissoco AC, Lezirovitz K
Journal Stem cell research
Publication Date 2023 Sep;71:103181
PubMed 37595341
DOI 10.1016/j.scr.2023.103181

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