Generation of an induced pluripotent stem cell line from an aortic dissection patient carrying MCTP2/c.2635T > G mutation


Aortic dissection (AD) is a lethal cardiovascular disease that is related to a genetic mutation. This study showed the generation of induced pluripotent stem cell (iPSC) line (iPSC-ZPR-4-P10) from AD patients' peripheral blood mononuclear cells that carried a c.2635T > G mutation in MCTP2. The iPSC line demonstrated normal karyotype and expression of pluripotency markers, which could be an efficient tool to better investigate the mechanism of aortic dissection. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Feng W, Li C, Li Y, Yang J, Fan R
Journal Stem cell research
Publication Date 2023 Feb 26;68:103058
PubMed 36868039
DOI 10.1016/j.scr.2023.103058

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