Recapitulation of dyssynchrony-associated contractile impairment in asymmetrically paced engineered heart tissue


This model allows for long-term pacing experiments mimicking electrical dyssynchrony vs. synchrony in vitro. Combined with force measurement and afterload stimulus manipulation, it provides a robust new tool to gain insight into the biology of dyssynchrony and CRT. Copyright © 2021. Published by Elsevier Ltd.

Authors Stenzig J, Lemoine MD, Stoter AMS, Wrona KM, Lemme M, Mulla W, Etzion Y, Eschenhagen T, Hirt MN
Journal Journal of molecular and cellular cardiology
Publication Date 2022 Feb;163:97-105
PubMed 34634355
PubMed Central PMC8828044
DOI 10.1016/j.yjmcc.2021.10.001

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