Recapitulation of dyssynchrony-associated contractile impairment in asymmetrically paced engineered heart tissue
Summary
This model allows for long-term pacing experiments mimicking electrical dyssynchrony vs. synchrony in vitro. Combined with force measurement and afterload stimulus manipulation, it provides a robust new tool to gain insight into the biology of dyssynchrony and CRT. Copyright © 2021. Published by Elsevier Ltd.
| Authors | Stenzig J, Lemoine MD, Stoter AMS, Wrona KM, Lemme M, Mulla W, Etzion Y, Eschenhagen T, Hirt MN |
|---|---|
| Journal | Journal of molecular and cellular cardiology |
| Publication Date | 2022 Feb;163:97-105 |
| PubMed | 34634355 |
| PubMed Central | PMC8828044 |
| DOI | 10.1016/j.yjmcc.2021.10.001 |