Using genetically engineered iPSCs to model ALS
| Title | Using genetically engineered iPSCs to model ALS |
|---|---|
| Acronym | PhaseAge-iPSC |
| Website | https://www.mpi-cbg.de/research-groups/current-groups/simon-alberti/research-focus/ |
| Start date | 2017-04-01 |
| End date | 2021-03-31 |
Associated cell lines
Project Description
An iPS cell line derived from a fibroblast line from a healthy control individual was generated by reprogramming. The resulting T12.9 cell line will be genetically modified to generate a library of isogenic iPSCs with changes in ALS relevant genes. These iPSCs will be differentiated into motor neurons and used as cellular models to characterize molecular changes underlying ALS.