Mechanisms of spinal cord plasticity studied with hES cells
|Title||Mechanisms of spinal cord plasticity studied with hES cells|
|Institution||University of Oslo|
Associated cell lines
Synaptic plasticity in the spinal cord represents a potential mechanism for achieving functional recovery after spinal cord injury. In this project, we are generating hES cells that are genetically manipulated to up- or down-regulate the expression of proteins involved in synapse formation, with the aim of differentiating human neural progenitors and neurons that can be used to test how such manipulations influence the capacity for integration into functional synaptic circuits.