Cellular modulation by the mitochondrial unfolded protein response

Title	Cellular modulation by the mitochondrial unfolded protein response
Acronym	mitoUPR
Website	http://pqc.biochem2.de/
Start date	2020-02-01
End date	2024-01-31
Sponsor	European Research Council - Starting Grant (ERC-StG)
Institution	Goethe University Frankfurt, IBC2, Münch lab

Associated cell lines

• WTSIi013-A (HPSI0214i-kucg_2)
• WTSIi046-A (HPSI0214i-wibj_2)

Project Description

Mitochondrial function is central for cellular metabolism and energy balance. However, many diseases, including cancer and neurodegenerative diseases, affect mitochondrial function and proteostasis. Upon mitochondrial protein misfolding, mitochondria activate the mitochondrial unfolded protein response (UPRmt) to restore proteostasis, a poorly characterized pathway in mammalian cells. Notably, the effects of the UPRmt on its direct environment – mitochondria – and on cytosolic homeostasis remain unknown. We aim at determining the role of the UPRmt on mitochondria, cytosol, and neighboring cells, including producing relevant iPSC-based UPRmt models.