Cellular modulation by the mitochondrial unfolded protein response
|Title||Cellular modulation by the mitochondrial unfolded protein response|
|Sponsor||European Research Council - Starting Grant (ERC-StG)|
Associated cell lines
Mitochondrial function is central for cellular metabolism and energy balance. However, many diseases, including cancer and neurodegenerative diseases, affect mitochondrial function and proteostasis. Upon mitochondrial protein misfolding, mitochondria activate the mitochondrial unfolded protein response (UPRmt) to restore proteostasis, a poorly characterized pathway in mammalian cells. Notably, the effects of the UPRmt on its direct environment – mitochondria – and on cytosolic homeostasis remain unknown. We aim at determining the role of the UPRmt on mitochondria, cytosol, and neighboring cells, including producing relevant iPSC-based UPRmt models.