Cellular modulation by the mitochondrial unfolded protein response

Title Cellular modulation by the mitochondrial unfolded protein response
Acronym mitoUPR
Website http://pqc.biochem2.de/
Start date 2020-02-01
End date 2024-01-31
Sponsor European Research Council - Starting Grant (ERC-StG)

Associated cell lines

Project Description

Mitochondrial function is central for cellular metabolism and energy balance. However, many diseases, including cancer and neurodegenerative diseases, affect mitochondrial function and proteostasis. Upon mitochondrial protein misfolding, mitochondria activate the mitochondrial unfolded protein response (UPRmt) to restore proteostasis, a poorly characterized pathway in mammalian cells. Notably, the effects of the UPRmt on its direct environment – mitochondria – and on cytosolic homeostasis remain unknown. We aim at determining the role of the UPRmt on mitochondria, cytosol, and neighboring cells, including producing relevant iPSC-based UPRmt models.