Modulating the gut microbiome to enhance drug efficacy
| Title | Modulating the gut microbiome to enhance drug efficacy |
|---|---|
| Acronym | BugDrug |
| Start date | 2021-06-01 |
| End date | 2026-06-01 |
| Sponsor | European Research Council - Consolidator Grant (ERC-CoG) |
| Principal investigator | Jingyuan Fu
E-Mail: j.fu@umcg.nl |
Project Description
Individualized drug testing in vitro is an urgently needed tool to aid personalized medicine. Such a model should be able to trace the chemical transformations of drugs and mimic the mechanical, structural, absorptive, transport, and pharmaceutical properties of drugs along the microbe-gut-liver axis. Linked gut-on-a-chip and liver-on-a-chip systems that mimic metabolically critical physiological functions have been recognized to be more effective than static mono-organ-on-a-chip systems. The project aims to develop such a system that mimics the metabolic flow through the gut and liver by generating iPSC-derived gut-on-a-chip and liver-on-a-chip from the same individuals and study the gut/microbe-liver axis in drug metabolism.