Modulating the gut microbiome to enhance drug efficacy
|Title||Modulating the gut microbiome to enhance drug efficacy|
|Sponsor||European Research Council - Consolidator Grant (ERC-CoG)|
|Principal investigator||Jingyuan Fu
Individualized drug testing in vitro is an urgently needed tool to aid personalized medicine. Such a model should be able to trace the chemical transformations of drugs and mimic the mechanical, structural, absorptive, transport, and pharmaceutical properties of drugs along the microbe-gut-liver axis. Linked gut-on-a-chip and liver-on-a-chip systems that mimic metabolically critical physiological functions have been recognized to be more effective than static mono-organ-on-a-chip systems. The project aims to develop such a system that mimics the metabolic flow through the gut and liver by generating iPSC-derived gut-on-a-chip and liver-on-a-chip from the same individuals and study the gut/microbe-liver axis in drug metabolism.