Establishment of Heterozygous LMOD2 Knockout Human Embryonic Stem Cell Line Using CRISPR/Cas9 System
| Title | Establishment of Heterozygous LMOD2 Knockout Human Embryonic Stem Cell Line Using CRISPR/Cas9 System |
|---|---|
| Acronym | ZZUSAHi005-A |
| Start date | 2024-07-15 |
| End date | 2027-08-17 |
| Sponsor | zhhangchunjin |
| Institution | Zhengzhou University - The Second Affiliated Hospital of Zhengzhou University |
Associated cell lines
Project Description
Dilated cardiomyopathy (DCM) is a common cardiovascular disease characterized by impaired ventricular dilation and systolic function, with a complex etiology involving multiple genetic and environmental factors. The LMOD2 (Leiomodin 2) gene is implicated in the pathogenesis of DCM. This study aimed to establish a heterozygous LMOD2 knockout human embryonic stem cell (hESC) line using the CRISPR/Cas9 gene editing system to investigate the role of LMOD2 in DCM.