Synapsing Mental Disorders and Neurodegenerative diseases: Towards more effective diagnosis and management of psychiatric symptoms

Title	Synapsing Mental Disorders and Neurodegenerative diseases: Towards more effective diagnosis and management of psychiatric symptoms
Acronym	SYNAPSING
Website	https://cordis.europa.eu/project/id/101156566
Start date	2025-01-01
End date	2029-12-31
Sponsor	Horizon Europe
Institution	NMI Natural and Medical Sciences Institute at the University of Tübingen

Associated cell lines

• NMIi001-A
• NMIi002-B
• NMIi004-A
• NMIi005-A
• NMIi006-A

Project Description

Synaptic dysfunction contributes to emotional, behavioural and cognitive symptoms, often overlapping in mental disorders (MDs) and neurodegenerative disorders (NDs). Pharmaceutical treatments of these symptoms are often ineffective in both types of disorders. Working with MD and ND clinics, the EU-funded SYNAPSING project will produce the first trans-European collection of clinical, neuroimaging and socioeconomic data from more than 3 000 patients. SYNAPSING will search the data for blood biomarkers for better diagnosis, treatment and treatment monitoring. The project will also use post-mortem brain tissue and neurons from MD and ND patients to model synapse dysfunction. Finally, the consortium will address socio-economic disparities impacting healthcare by identifying modifiable socio-economic risk factors for psychiatric symptoms.