Generation and Characterization of a Human-Derived iPSC line from a female child with First-Episode of sporadic schizophrenia
Summary
Schizophrenia is a highly heritable neurodevelopmental disorder. In this study, peripheral blood mononuclear cells (PBMCs) were obtained from a female child diagnosed with first-episode of sporadic schizophrenia. Induced pluripotent stem cells (iPSCs) were generated by introducing the reprogramming factors OCT4, SOX2, NANOG, LIN28, c-MYC, KLF4, and SV40LT. The iPSC line was confirmed through karyotyping and the expression of key pluripotency markers. These cells demonstrated the ability to differentiate into all three germ layers in vivo. Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Jiang Y, Zhou C, Zhao J, Ren X, Wang Q, Ni P, Li T |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Aug;86:103713 |
| PubMed | 40280000 |
| DOI | 10.1016/j.scr.2025.103713 |