Generation of an induced pluripotent stem cell line, JHUi008-A, from a healthy female donor
Summary
The use of well characterized human induced pluripotent stem cells (hiPSCs) is essential for developmental studies and disease modeling. Here, we report the generation of a normal, female line of hiPSCs following reprogramming of peripheral blood mononuclear cells (PBMCs) derived from a healthy female donor using Sendai virus technology. This line, which has been extensively employed for the in vitro study of mesoderm-derived cardiomyocytes, is available and registered in the Human Pluripotent Stem Cell Registry (hPSCreg). It exhibits a normal karyotype, expresses stemness markers, and demonstrates robust trilineage differentiation potential. Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Chua CJ, DiSilvestre D, Joshi-Mukherjee R, Tung L, Tomaselli GF, Boheler KR |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Aug 24;88:103819 |
| PubMed | 40912204 |
| DOI | 10.1016/j.scr.2025.103819 |