Generation of an induced pluripotent stem cell line from a malignant melanoma patient who developed the immune checkpoint inhibitor-related myasthenia gravis, myositis, and myocarditis overlap syndrome
Summary
Immune checkpoint inhibitors (ICI) are a pivotal class of immuno-oncology therapeutics that have improved survival rates for patients with cancer. Their widespread usage, however, is limited due to the development of serious and potentially deadly ICI-related side effects. To develop novel diagnostic and therapeutic strategies to identify and treat patients at risk, we need a better understanding of the underlying mechanisms mediating these potentially deadly side effects. To reach this goal, we have generated and validated induced pluripotent stem cells from the peripheral blood mononuclear cells of a melanoma patient who developed ICI-related myasthenia gravis, myositis, and myocarditis overlap syndrome. Published by Elsevier B.V.
| Authors | Huynh DTN, Noishiki C, Lai J, Yarahmadi P, Le T, Tripathi D, Tacco IR, Manhas A, Sallam K, Chen IY, Sayed N, Nguyen PK |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Sep;87:103797 |
| PubMed | 40795579 |
| PubMed Central | PMC12450033 |
| DOI | 10.1016/j.scr.2025.103797 |