Development of an iPSC-based screening platform identifying enhancers of chondrogenesis
Summary
Our findings further demonstrate how the small molecules pro-chondrogenic effects are dependent on the screening platform conditions, including the cell type, molecule concentration, 3D culture, hypoxia, and the inclusion of additional growth factors. The iPSC-based screening platform developed has the potential to identify disease modifying OA drugs (DMOADs) in novel compound screening libraries. © 2025 The Authors.
| Authors | O'Brien A, Xu M, O'Connell E, Morrison AM, Shaw G, Dutton JR, Murphy M, Barry F |
|---|---|
| Journal | Osteoarthritis and cartilage open |
| Publication Date | 2025 Dec;7(4):100680 |
| PubMed | 41069380 |
| PubMed Central | PMC12506548 |
| DOI | 10.1016/j.ocarto.2025.100680 |