Generation of induced pluripotent stem cell line UJSi005-A from developmentally delayed schizophrenic patients
Summary
Schizophrenia, a chronic mental health condition, is characterized by abnormalities in perception, emotions and behavior. We successfully generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells (PBMCs) of a patient with schizophrenia and neurodevelopmental delay who responded well to olanzapine therapy. The iPSCs exhibited a normal karyotype, expressed markers of undifferentiated human pluripotent stem cells (hPSCs), and differentiated into the three germ layers in vivo. Copyright © 2025. Published by Elsevier B.V.
| Authors | Xu X, Xue B, Zhang D, Wang Y, Chen B, Shan Z, Zhao W, Qiu T, Sun J, Qin S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Oct 13;89:103854 |
| PubMed | 41115334 |
| DOI | 10.1016/j.scr.2025.103854 |