Generation of integration-free human induced pluripotent stem cell line MUi040-A derived from CD34 + hematopoietic stem cells of a patient with constitutional pericentric inversion of chromosome 9
Summary
The MUi040-A human induced pluripotent stem cell (hiPSC) line was established from CD34 + hematopoietic stem cells of a male patient with senile amyloidosis. Patient carries a unique chromosome inversion at bands 9p12 and 9q13, which is one of the most common variants of the normal karyotype of chromosome 9 (inv[9]). This hiPSC line maintains an identical karyotype to that of the parental cells. MUi040-A expressed pluripotency markers and demonstrated the capacity to differentiate into all three germ layers. This cell line offers a valuable in vitro for studying the pathophysiology of senile systemic amyloidosis and for evaluating potential therapeutic approaches. Copyright © 2025. Published by Elsevier B.V.
| Authors | Linn AK, Phanthong P, Pewkliang Y, Laosee W, Tong-Ngam P, Tubsuwan A, Trachoo O, Asavapanumas N, Borwornpinyo S, Hongeng S, Yingchoncharoen T |
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| Journal | Stem cell research |
| Publication Date | 2025 Nov 4;89:103866 |
| PubMed | 41223746 |
| DOI | 10.1016/j.scr.2025.103866 |