Promoting differentiation of human-induced pluripotent stem cells into sinoatrial node-like cells through programmed regulation of AMPK signalling pathway
Summary
Early activation and then inhibition of the AMPK signalling pathway during the differentiation process can promote hiPSC differentiation to SANLCs, which may provide a novel strategy for obtaining SANLCs for studies on SAN diseases. © The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.
| Authors | Liu F, Xue Z, Lan H, Wan J, Yang C, Cyganek L, Hamdani N, Yu F, Liao B, Zhou X, El-Battrawy I, Akin I |
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| Journal | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology |
| Publication Date | 2025 Oct 31;27(11) |
| PubMed | 41206581 |
| PubMed Central | PMC12648565 |
| DOI | 10.1093/europace/euaf288 |