Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs
Summary
Hyperthermia exacerbated the BrS phenotype in hiPSC-CMs carrying SCN10A and SCN5A variants, whereas LPS aggravated the phenotype in all three BrS variants through distinct mechanisms; Hyperthermia and LPS effects on BrS phenotype may be genotype-dependent. © 2025. The Author(s).
| Authors | Li Y, Rose L, Prädel T, Kleinsorge M, Fan X, Meng Z, Yan C, Liu R, Lei X, Zhao B, Yang G, Liao Z, Dinkel H, Busley AV, Zhong R, Zhang F, Xu Q, Maywald L, Aweimer A, Huang M, Moscu-Gregor A, Hamdani N, Schneider L, Zemedi Y, Zhazykbayeva S, Hohn A, Yang Z, Qiao L, Mügge A, Cyganek L, Zhou X, Akin I, El-Battrawy I |
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| Journal | Stem cell research & therapy |
| Publication Date | 2025 Dec 1;16(1):670 |
| PubMed | 41327470 |
| PubMed Central | PMC12670799 |
| DOI | 10.1186/s13287-025-04793-6 |