Generation of the human iPSC line ESi148-A from a patient with sporadic amyotrophic lateral sclerosis
Summary
Nearly 90% of patients with amyotrophic lateral sclerosis (ALS) do not carry mutations in genes previously associated with the disease and are classified as sporadic cases with no identified genetic cause. In this study, peripheral blood mononuclear cells from a patient with sporadic ALS were reprogrammed to generate the human induced pluripotent stem cell (iPSC) line ESi148-A. The line was thoroughly characterized for pluripotency and genomic stability. These cells provide a valuable resource for generating 3D biomodels, such as cortical or spinal cord organoids, to investigate disease mechanisms and develop novel therapeutic approaches for sporadic ALS. Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Garcia-Delgado AB, Bega S, Campos-Cuerva R, Martín-Banderas L, Paradas C, Fernandez-Muñoz B |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Dec 15;90:103889 |
| PubMed | 41420983 |
| DOI | 10.1016/j.scr.2025.103889 |