Generation of an induced pluripotent stem cell line from a patient with Varicose veins
Summary
Chronic venous disease is among the most common vascular diseases globally. Varicose veins (VV), characterized by permanent dilation, elongation, and tortuosity of superficial veins, is a manifestation of chronic venous disease. Here, we generated an induced pluripotent stem cell (iPSC) line from PBMCs obtained from a patient with VV. The iPSC line exhibited typical morphology, maintained undifferentiated hPSC state markers, demonstrated a normal karyotype, and successfully differentiated into all three germ layers. This iPSC line provides a valuable platform to model VV pathogenesis and investigate the molecular mechanisms underlying venous dysfunction. Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Noishiki C, Manhas A, Adkar SS, Tripathi D, Wu D, Sadat S, Liu L, Sallam K, Leeper NJ, Fukaya E, Sayed N |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Dec;89:103850 |
| PubMed | 41075513 |
| PubMed Central | PMC12757079 |
| DOI | 10.1016/j.scr.2025.103850 |