T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology
Summary
Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 (LMO2), rather than by the target cell phenotype. This approach allowed to identify that secondary genomic alterations, like Notch1 mutations, appeared late and only took place within the thymus during T-ALL development. These concepts are therefore critical for the development of modern therapies aimed at curing T-ALL.
| Authors | Rodríguez-Hernández G, Bhatia S, Vicente-Dueñas C, Borkhardt A, Hauer J, Sánchez-García I |
|---|---|
| Journal | Molecular & cellular oncology |
| Publication Date | 2018;5(4):e1497860 |
| PubMed | 30250933 |
| PubMed Central | PMC6150050 |
| DOI | 10.1080/23723556.2018.1497860 |