Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient
Summary
Human induced pluripotent stem cell (hiPSC) line FLENIi004-A was generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi004-A was derived from a 41-year-old Argentinean Caucasian male patient with Autosomal-Dominant Alzheimer's Disease, who carried the heterozygous PSEN1 p.M146L mutation. The hiPSC line retained the PSEN1 mutation, and its pluripotency and trilineage differentiation potential were confirmed. Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Vautier MF, Chrem Mendez P, Jerez Ferreyra G, Massazza V, Apecetche M, Rodríguez Varela MS, Clas G, Nievas M, Allegri R, Sevlever GE, Scassa ME, Surace EI, Marazita MC, Romorini L |
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| Journal | Stem cell research |
| Publication Date | 2026 Mar 6;93:103958 |
| PubMed | 41819741 |
| DOI | 10.1016/j.scr.2026.103958 |