The human induced pluripotent stem cell line CTGUi-002A was generated from a Perrault syndrome patient
Summary
We generated an induced pluripotent stem cell (iPSC) line, designated CTGUi002-A, from peripheral blood mononuclear cells (PBMCs) of a 9-year-old female with Perrault syndrome carrying biallelic TWNK mutations (c.811G>A and c.1163C>T), using Sendai virus-mediated delivery of OCT4, SOX2, KLF4, and c-MYC. The CTGUi002-A iPSC line retained the TWNK mutations and exhibited characteristic iPSC morphology, expressed pluripotency markers, maintained a normal karyotype, and demonstrated trilineage differentiation potential. Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Wu SL, Li Y, Dou T, Wang W, Zhan JQ, Lv YF |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Apr;92:103929 |
| PubMed | 41722370 |
| DOI | 10.1016/j.scr.2026.103929 |