Generation of a human induced pluripotent stem cell line NTUHi007-A from a patient with Parkinson's disease harboring a heterozygous missense mutation c.1858 G > A (p.D620N) in VPS35 gene
Summary
Vacuolar protein sorting 35 (VPS35) is a rare autosomal dominant cause of Parkinson's disease (PD), typically presenting with levodopa-responsive motor symptoms similar to idiopathic PD. Using a Sendai virus-based system, we generated an induced pluripotent stem cell line from peripheral blood mononuclear cells of a 48-year-old woman carrying a heterozygous VPS35 c.1858G > A (p.D620N) mutation. This cellular model provides a valuable tool for investigating pathogenic mechanisms and facilitating the development of potential PD therapies. Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Chen YF, Ou-Yang CH, Lin CH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Mar 4;93:103955 |
| PubMed | 41806467 |
| DOI | 10.1016/j.scr.2026.103955 |