Establishment of CSUASOi014-A, an induced pluripotent stem cell line from blood-derived cells of a Chinese patient carrying PRPF31 gene mutation
Summary
Retinitis pigmentosa (RP) is a group of inherited retinal degenerative disorders characterized by progressive visual dysfunction. In this study, we generated an induced pluripotent stem cell (iPSC) line, CSUASOi014-A, from peripheral blood cells of a 40-year-old Chinese female patient clinically diagnosed with RP. Peripheral blood mononuclear cells were isolated and reprogrammed using an integration-free Sendai virus system. The established iPSC line harbors a heterozygous PRPF31 c.528-39_531del mutation. CSUASOi014-A provides a patient-specific cellular resource for studying the pathogenic mechanisms underlying PRPF31-associated RP. Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Liang Y, Sun X, Liang Y, Chen H, Duan C, Chen Y, Li W, Gu J, Cui Z, Ding C, Chen J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Mar 16;93:103965 |
| PubMed | 41864154 |
| DOI | 10.1016/j.scr.2026.103965 |