The association between omega-3 supplementation and cognitive decline in older adults
Summary
Omega-3 supplementation may be associated with accelerated cognitive decline in older adults, potentially through adverse effects on cerebral synaptic function rather than classical AD proteinopathies. These findings challenge the prevailing view of omega-3 as uniformly beneficial and highlight the need for a cautious reassessment of its widespread use for cognitive protection. Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
| Authors | Liao ZB, Hu ZC, Zeng GH, Chen J, Li XP, Liu YH, Yao XQ, Wang YR, Alzheimer’s Disease Neuroimaging Initiative |
|---|---|
| Journal | The journal of prevention of Alzheimer's disease |
| Publication Date | 2026 Jun;13(6):100569 |
| PubMed | 42000571 |
| PubMed Central | PMC13099475 |
| DOI | 10.1016/j.tjpad.2026.100569 |