Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from ovarian fibroblasts
Summary
Curative bone marrow transplantation (BMT) therapies for sickle cell disease (SCD) can cause infertility. The Fertility Preservation Program (FPP) in Pittsburgh cryopreserves ovarian tissues for SCD patients prior to BMT in anticipation that these tissues can be used in the future to produce eggs and achieve a pregnancy. Here, we generated and validated two isogenic patient-derived induced pluripotent stem cell (iPSC) lines from ovarian cortex fibroblasts of a 28-year-old SCD patient. Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Harancher MR, Myklebust LK, Sukhwani M, Kanodia C, Sheng Y, Castro CA, Colvin Zielen AM, Orwig KE |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Apr;92:103936 |
| PubMed | 41719743 |
| PubMed Central | PMC13077771 |
| DOI | 10.1016/j.scr.2026.103936 |