Generation of an induced pluripotent stem cell line (KCGMHi001-A) from a patient with CEP85L related posterior predominant lissencephaly (LIS10)
Summary
Lissencephaly type 10 (LIS10, OMIM#618873) is a rare neurodevelopmental disorder characterized by posterior-predominant pachygyria/agyria or subcortical band heterotopia on brain imaging. Clinically, affected individuals exhibit a range of developmental delays, including intellectual disability, language impairment, and frequently intractable epilepsy. LIS10 results from pathogenic variants in the centrosomal gene CEP85L. Peripheral blood mononuclear cells obtained from a LIS10 patient were reprogrammed into induced pluripotent stem cells (iPSC; line KCGMHi001-A) using Sendai virus. This iPSC model serves as a valuable resource for future mechanistic studies and therapeutic development for LIS10. Copyright © 2026. Published by Elsevier B.V.
| Authors | Hou PS, Lim SJ, Lu HE, Tsai MH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Apr 27;94:104004 |
| PubMed | 42066409 |
| DOI | 10.1016/j.scr.2026.104004 |