Generation of 4 human induced pluripotent stem cell lines (LUMCi070-A, -B, -C, and -D) from a patient with ischemic cerebral small vessel disease
Summary
We generated induced pluripotent stem cells (iPSCs) from a patient with ischemic small vessel disease carrying a likely pathogenic variant in the APP gene. These iPSCs show expression of pluripotency markers on RNA and protein level, as well as the ability to differentiate into all three germ layers. They can be used to investigate disease mechanisms and support the development of new therapies. Copyright © 2026. Published by Elsevier B.V.
| Authors | Voesenek BJB, van der Graaf LM, Lesnik Oberstein SAJ, van Roon-Mom WMC, Daoutsali E, Buijsen RAM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Jun 14;95:104036 |
| PubMed | 42296843 |
| DOI | 10.1016/j.scr.2026.104036 |