Generation of an induced pluripotent stem cell line (HMSCATi007-A) from an epileptic patient with DEPDC5 gene mutation
Summary
Familial Focal Epilepsy with Variable Foci 1 (FFEVF1) is an autosomal dominant epilepsy disorder characterized by focal seizures. Induced pluripotent stem cells (iPSCs) were derived from a 21-year-old epileptic patient carrying a heterozygous DEPDC5 c.2748 (C > G) (exon 29) variant. The derived iPSCs maintain a normal karyotype, express pluripotency markers, and retain the ability to differentiate into the three germ layers. iPSCs are for research use only, including scientific research and the development of anti-epileptic therapeutics. Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Li X, Chunyan Z, Lu M, Wang J, Ren W, Shan W, Ren Q, Wang Q |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Jul 28;95:104067 |
| PubMed | 42561553 |
| DOI | 10.1016/j.scr.2026.104067 |