Generation of induced pluripotent stem cell line NTUHi003-A from a patient with premature ovarian insufficiency
Summary
Premature ovarian insufficiency (POI) is characterized by impaired ovarian function before 40 years of age and is associated with heterogeneous etiologies. Herein, we established a human induced pluripotent stem cell (hiPSC) line, NTUHi003-A, from the peripheral blood mononuclear cells (PBMCs) of a patient with POI. The generated hiPSC line exhibited a normal 46, XX karyotype and demonstrated confirmed pluripotency. This cell line provides a valuable cellular platform for disease modeling and mechanistic studies of POI. Copyright © 2026. Published by Elsevier B.V.
| Authors | Chen YA, Lu CY, Wu CE, Chen TH, Lu HE, Chen HF, Huang CC |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Aug 11;95:104076 |
| PubMed | 42603520 |
| DOI | 10.1016/j.scr.2026.104076 |