Generation of a human induced pluripotent stem cell line (HEBHMUi019-A) from a 67-year-old male Alzheimer's patient with APOE-ε4/ε4 genotype
Summary
Apolipoprotein E (apoE), encoded by the polymorphic APOE gene, plays a key role in lipid transport and metabolism. The three major APOE alleles are ε2, ε3, and ε4, with ε4 being the strongest genetic risk factor for late-onset Alzheimer's disease. We generated human induced pluripotent stem cells from peripheral blood mononuclear cells of a 67-year-old male patient with Alzheimer's disease carrying the APOE ε4/ε4 genotype. The generated cell line displayed typical iPSC morphology, a normal karyotype, trilineage differentiation potential, and pluripotency-marker expression, providing a resource for investigating APOE ε4-associated disease mechanisms and preclinical therapeutic screening. Copyright © 2026. Published by Elsevier B.V.
| Authors | Ma J, Hua Z, Zhao B, Xu J, Bao K, Guo R |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Aug 13;95:104082 |
| PubMed | 42603521 |
| DOI | 10.1016/j.scr.2026.104082 |