Microglia derived from human induced pluripotent stem cells are regulated by osteopontin, an endogenous extracellular matrix protein maintaining immune homeostasis
Summary
OPN induced a distinct early response profile in hiPSC-derived microglia, characterized by intermediate morphological remodeling, increased CD68 intensity, and reduced homeostatic gene expression, without overt pro-inflammatory gene expression. These findings support the role of OPN as a physiological priming signal in microglia and highlight hiPSC-derived microglia as a model for studying regulators of microglial modulation. Copyright © 2026 Olschewski, Koenig, Nerone, Gross, Šarić, Vay, Schroeter, Fink and Rueger.
| Authors | Olschewski DN, Koenig AM, Nerone HM, Gross E, Šarić T, Vay SU, Schroeter M, Fink GR, Rueger MA |
|---|---|
| Journal | Frontiers in neuroscience |
| Publication Date | 2026;20:1785992 |
| PubMed | 42422253 |
| PubMed Central | PMC13342188 |
| DOI | 10.3389/fnins.2026.1785992 |