High-fidelity genome and prime editing enabled by the AI-designed openCRISPR-1
Summary
These findings establish generative AI-guided protein design as a powerful strategy to overcome the specificity-efficiency trade-off, expanding the genome editing toolkit for both research and therapeutic use, and ushering in a new era of rational protein design. © 2026. The Author(s).
| Authors | Hwang HY, Yi H, Gwon Y, Jeon E, Kim D |
|---|---|
| Journal | Genome medicine |
| Publication Date | 2026 May 26;18(1) |
| PubMed | 42192532 |
| PubMed Central | PMC13393691 |
| DOI | 10.1186/s13073-026-01682-2 |