Beyond animal models: using human pluripotent stem cell-derived stem and progenitor cells to predict cytotoxicity in normal tissues
Summary
Human iPSC-derived stem/progenitor cells recapitulate the in vivo sensitivity of healthy dividing cell populations to chemotherapy. This platform offers unlimited, genetically consistent, and reproducible access to human cells, rendering it as a powerful complementary approach or even an alternative to animal models and primary human cells for early-phase drug safety profiling. Copyright © 2026 Vincze, Varga, Tóth, Kis, Béres, Réthelyi, Veréb, Erdei, Sarkadi and Apáti.
| Authors | Vincze K, Varga N, Tóth S, Kis AK, Béres R, Réthelyi JM, Veréb ZJ, Erdei Z, Sarkadi B, Apáti Á |
|---|---|
| Journal | Pathology oncology research : POR |
| Publication Date | 2026;32:1612490 |
| PubMed | 42694232 |
| PubMed Central | PMC13538076 |
| DOI | 10.3389/pore.2026.1612490 |