A phase I/II study of human induced Pluripotent Stem (iPS) cell-derived cardiomyocyte spheroids in patients with severe heart failure, secondary to ischemic heart disease, undergoing coronary artery bypass grafting (LAPiS Study)

General Information

Clinical trials phase Phases 1/2
Start date (estimated) 2021-06-23
Clinical feature
Label heart failure
Link http://purl.obolibrary.org/obo/SYMP_0000292

Administrative Information

NCT number NCT04945018
ICTRP weblink https://trialsearch.who.int/Trial2.aspx?TrialID=JPRN-jRCT2033210163
Other study identifiers
Name jRCT2033210163
Description Japan Registry of Clinical Trials (jRCT)
Name HS-001-01
Source weblink https://jrct.niph.go.jp/en-latest-detail/jRCT2033210163
Public contact
Email contact@heartseed.jp
Public email contact@heartseed.jp
Sponsors Heartseed Inc.


Which differentiated cell type is used
Label cardiac muscle cell
Link http://purl.obolibrary.org/obo/CL_0000746
Description Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.; This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.


Recruitment Status Recruiting
Estimated number of participants 10