A phase I/II study of human induced Pluripotent Stem (iPS) cell-derived cardiomyocyte spheroids in patients with severe heart failure, secondary to ischemic heart disease, undergoing coronary artery bypass grafting (LAPiS Study)

Clinical trials phase

Phases 1/2

Start date (estimated)

2021-06-23

Clinical feature

Label	heart failure
Link	http://purl.obolibrary.org/obo/SYMP_0000292

NCT number

NCT04945018

ICTRP weblink

Other study identifiers

Name	jRCT2033210163
Description	Japan Registry of Clinical Trials (jRCT)

Name	HS-001-01

Source weblink

Public contact

chiken@heartseed.jp

Public email

chiken@heartseed.jp

First name

Madoguchi

Last name

Toiawase

Phone

+81-3-6380-1068

City

Tokyo

Country

Japan

Which differentiated cell type is used

Label	cardiac muscle cell
Link	http://purl.obolibrary.org/obo/CL_0000746
Description	Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.; This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.

Recruitment Status

Recruiting

Estimated number of participants