Evaluation of knee function and safety after treatment of knee articular cartilage damage with iPS-cell-derived cartilage

General Information

Clinical trials phase Long term follow up
Start date (estimated) 2022-06-16
Clinical feature
Label articular cartilage disease
Link http://purl.obolibrary.org/obo/DOID_6227
Description A cartilage disease that is characterized by damage to the cartilage that covers the ends of the bones.

Administrative Information

ICTRP weblink https://trialsearch.who.int/Trial2.aspx?TrialID=JPRN-jRCT1050220051
Other study identifiers
Name jRCT1050220051
Description Japan Registry of Clinical Trials (jRCT)
Source weblink https://jrct.niph.go.jp/en-latest-detail/jRCT1050220051
Public contact
Email seikei@kuhp.kyoto-u.ac.jp
Public email seikei@kuhp.kyoto-u.ac.jp
First name Kuriyama
Last name Shinichi
City Kyoto
Country
Japan
Address freetext 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Sponsors Kyoto University Hospital

Cells

Which differentiated cell type is used
Label cartilage tissue
Link http://purl.obolibrary.org/obo/UBERON_0002418
Description Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.; Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]

Recruitment

Recruitment Status Recruiting
Estimated number of participants 4