A Clinical Research on the Safety of Hepatocytes Therapy Generated from Human Embryonic Stem Cells for Patients with Acute or Acute-on-Chronic Liver Failure

General Information

Clinical trials phase Other
Start date (estimated) 2022-01-01
End date (estimated) 2024-10-31
Clinical feature
Label Acute liver failure
Link http://www.orpha.net/ORDO/Orphanet_90062
Description A rare hepatic disease characterized by acute onset of severe liver dysfunction without evidence of underlying chronic liver disease. Patients present with nonspecific symptoms like jaundice, upper right abdominal pain, nausea, vomiting, pruritus, fatigue, and fever. The condition may rapidly progress to hepatic encephalopathy, coagulopathy, and life-threatening multiorgan failure. Liver biopsy typically shows massive hepatic necrosis.

Administrative Information

ICTRP weblink https://trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2100052988
Other study identifiers
Name ChiCTR2100052988
Description Chinese Clinical Trial Registry (ChiCTR)
Source weblink http://www.chictr.org.cn/showprojen.aspx?proj=133608
Public contact
Email 70950808@qq.com
Public email 70950808@qq.com
First name Sun
Last name Yi
Phone +86 731 88395675
City Changsha
Address freetext 8 Luyun Road, Yuelu District, Changsha, Hunan, China
Sponsors Xiangya Hospital Central South University


Which differentiated cell type is used
Label hepatocyte
Link http://purl.obolibrary.org/obo/CL_0000182
Description The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.; Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.


Recruitment Status Not yet recruiting
Estimated number of participants 10